![]() McAvoy's television work includes a minor role in the HBO war drama miniseries Band of Brothers (2001), the thriller State of Play (2003) and the science fiction miniseries Frank Herbert's Children of Dune (2003). He has starred in the science fiction horror film Victor Frankenstein with Daniel Radcliff (2015), action thriller film Atomic Blonde with Charlize Theron (2017), and played Bill Denbrough in the supernatural horror film It Chapter Two, the second installment of the It film series based on Stephen King's 1986 novel of the same name. Night Shyamalan's Split, for which he received critical acclaim, and later reprised the role for the sequel Glass (2019). In 2016, he portrayed Kevin Wendell Crumb, a man with 23 alternate personalities, in M. A year later, he starred with Jessica Chastain in the drama film The Disappearance of Eleanor Rigby, the collective title of three films split into three parts, Him, Her and Them. McAvoy starred in the 2013 crime comedy-drama film Filth, for which he won Best Actor in the British Independent Film Awards. He has played the role in the superhero films X-Men: First Class (2011), X-Men: Days of Future Past (2014), X-Men: Apocalypse (2016), Deadpool 2 (2018), and Dark Phoenix (2019). In 2011, McAvoy was cast as Charles Xavier, a fictional character based on the Marvel Comics character of the same name. In 2008, he starred in the action thriller film Wanted opposite Angelina Jolie. He co-starred in the romance films Penelope with Christina Ricci (2006), Becoming Jane with Anne Hathaway (2007), and Atonement with Keira Knightley (2007). The following year, he starred in Kevin Macdonald's drama film The Last King of Scotland. Lewis's 1950 novel The Lion, the Witch and the Wardrobe. Tumnus in the 2005 fantasy film The Chronicles of Narnia: The Lion, the Witch and the Wardrobe, based on C. He appeared in the films Wimbledon (2004) and Inside I'm Dancing (2004), before being cast as Mr. ©2021 American Association for Cancer Research.Scottish actor James McAvoy made his acting debut as a teen in the 1995 film The Near Room with Andy Serkis. Pretreatment CTC, TP53 and PIK3 pathway mutations, and 8q gain were associated with poor outcome. Palbociclib did not impact outcome in RB-intact mHSPC. ![]() TP53 and PIK3 pathway mutations, 8q gains, and pretreatment CTCs were associated with reduced PSA PFS. ![]() Twelve-month biochemical PFS was 69% and 74% in Arms 1 and 2, respectively ( P = 0.72). PSA undetectable rate at 28 weeks was 50% and 43% in Arms 1 and 2, respectively ( P = 0.5). ![]() Eighty percent of patients (Arm 1: 16/20, Arm 2: 32/40 P = 0.87) met primary PSA endpoint ≤4 ng/mL at 28 weeks. Neutropenia was the most common grade 3/4 adverse event in Arm 2. A total of 60 patients initiated therapy (Arm 1: 20 Arm 2: 40). A total of 62 of 64 (97%) retained RB expression. Circulating tumor cells (CTC) were enumerated at various timepoints.Ī total of 72 patients with mHSPC underwent metastatic disease biopsy and 64 had adequate tissue for RB assessment. Tumors underwent exome sequencing when available. Secondary endpoints included safety, PSA, and clinical progression-free survival (PFS), as well as PSA and radiographic RR. Primary endpoint was PSA response rate (RR) after 28 weeks of therapy. We hypothesized that cotargeting androgen receptor and cell cycle with palbociclib would improve outcomes in patients with metastatic hormone-sensitive prostate cancer (mHSPC).Ī total of 60 patients with RB-intact mHSPC were randomized (1:2) to Arm 1: androgen deprivation (AD) or Arm 2: AD + palbociclib. Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor, blocks proliferation in a RB and cyclin D-dependent manner in preclinical prostate cancer models. ![]()
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